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Innehållsförteckning:

1. What is belatacept used for?
2. Can a belatacept-based regimen be used without CNIS or steroids?
3. Can belatacept be used for kidney transplantation?
4. Is belatacept a safe alternative to calcineurin inhibitors?
5. Can belatacept be used only in EBV-positive patients?
6. How often should I take belatacept after a kidney transplant?
7. What is belatacept used for?
8. Can I take other medications with belatacept?

What is belatacept used for?

Belatacept is used with other medicines to prevent organ rejection after a kidney transplant. Belatacept is given only to people who have been exposed to the Epstein-Barr virus (your doctor will test your blood to confirm this). Belatacept may also be used for purposes not listed in this medication guide.

Can a belatacept-based regimen be used without CNIS or steroids?

To investigate a belatacept-based regimen without CNIs or steroids, we transplanted recipients of live donor kidneys using alemtuzumab induction, monthly belatacept and daily sirolimus. Patients were randomized 1:1 to receive unfractionated donor bone marrow. After 1 year, patients were allowed to wean from sirolimus.

Can belatacept be used for kidney transplantation?

Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates.

Is belatacept a safe alternative to calcineurin inhibitors?

Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates. Experimentally, donor bone marrow and sirolimus promote belatacept's efficacy. To in …

Can belatacept be used only in EBV-positive patients?

• The decision to restrict belatacept for use only in EBV-positive patients was based on the findings of the phase 3 trials. The present report summarizes the final efficacy and safety results up to 7 years (84 months) after transplantation in the intention-to-treat population of BENEFIT.

How often should I take belatacept after a kidney transplant?

• Belatacept is usually given just before your kidney transplant, and again 5 days later, followed by once every 2 to 4 weeks. Follow your doctor's dosing instructions very carefully. Belatacept can increase your risk of infection by changing the way your immune system works.

What is belatacept used for?

• Belatacept is used to help prevent organ rejection in people who have received a kidney transplant. It is used along with other medications (such as mycophenolate, corticosteroids) to allow your new organ to function normally. Belatacept belongs to a class of drugs known as immunosuppressants.

Can I take other medications with belatacept?

• This medication can increase your risk for serious (even fatal) infections, such as cytomegalovirus or pneumocystis. To help prevent these serious infections, your doctor may direct you to also take other medications along with belatacept. Ask your doctor for details.